Skip to main content

GnRH Antagonist

Meaning

A GnRH antagonist is a synthetic peptide that competitively binds to and blocks the gonadotropin-releasing hormone (GnRH) receptors in the anterior pituitary gland, thereby rapidly inhibiting the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This immediate suppression distinguishes it from GnRH agonists, which initially cause a transient surge before achieving downregulation.