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Glycosaminoglycans

Meaning

Glycosaminoglycans (GAGs) are long, unbranched polysaccharides composed of repeating disaccharide units, one of which is an amino sugar. These highly negatively charged molecules are a major component of the extracellular matrix (ECM) and connective tissues throughout the body. Clinically significant GAGs include hyaluronic acid, chondroitin sulfate, and heparan sulfate. Their primary function is to attract and retain water, providing turgor, resilience, and lubrication to tissues like cartilage, skin, and joint fluid.