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Glycolytic Pathway Impairment

Meaning

Glycolytic Pathway Impairment refers to a reduction in the efficiency or capacity of glycolysis, the metabolic process that breaks down glucose into pyruvate to generate energy. This dysfunction is characterized by reduced glucose uptake, decreased activity of key glycolytic enzymes, or an accumulation of intermediate metabolites. Clinically, this impairment is a hallmark of insulin resistance and Type 2 Diabetes, significantly compromising the cell’s ability to utilize its primary fuel source, which has profound implications for overall hormonal and metabolic health.