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Glycolysis Downregulation

Meaning

Glycolysis Downregulation is the physiological process characterized by a reduction in the rate at which glucose is broken down into pyruvate and lactate to generate cellular energy (ATP). This metabolic shift signifies a decreased reliance on the glucose-burning pathway, often occurring in states of nutrient deprivation, such as fasting, or in response to specific hormonal signals. The downregulation is a key component of metabolic flexibility, encouraging cells to transition toward alternative, often more efficient, fuel sources like fatty acids or ketone bodies. This change is frequently observed in tissues demonstrating improved insulin sensitivity.