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Glycemic Load Cascade Failure

Meaning

Glycemic Load Cascade Failure describes a systemic breakdown in the body’s ability to efficiently manage and normalize blood glucose levels following the ingestion of high glycemic index and high glycemic load carbohydrates. This failure involves the rapid, excessive secretion of insulin, followed by subsequent insulin receptor desensitization and poor cellular glucose uptake. The clinical result is persistent postprandial hyperglycemia, which drives insulin resistance and metabolic syndrome. This condition represents a significant disruption to metabolic fuel substrate switching.