The maintenance of blood glucose concentrations within a tight, narrow physiological range, indicating robust and responsive regulation by insulin and counter-regulatory hormones. This stability reflects high fidelity in glucose sensing and appropriate secretion kinetics from pancreatic beta cells and alpha cells. Absence of significant glycemic excursions is a key indicator of metabolic health and insulin sensitivity.
Origin
Derived directly from clinical diabetology and metabolic research, the term emphasizes the dynamic aspect of glucose regulation over static measurements. “Stability” contrasts with lability, highlighting the need for consistent homeostatic control rather than merely achieving a target average. It is a core metric when evaluating the effectiveness of metabolic interventions.
Mechanism
Stable glycemic control depends fundamentally on efficient insulin signaling cascades within peripheral tissues, allowing for rapid glucose uptake postprandially. Furthermore, appropriate glucagon suppression during hyperglycemia and timely release during hypoglycemia are critical components. Hormonal factors like cortisol and growth hormone must also maintain appropriate permissive effects without inducing undue insulin resistance.
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