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Glycation Endpoint Mitigation

Meaning

Glycation Endpoint Mitigation refers to clinical strategies aimed at reducing the formation and accumulation of Advanced Glycation End-products (AGEs), which are detrimental compounds formed when sugars react non-enzymatically with proteins or lipids. Excessive AGEs accelerate tissue aging, compromise vascular health, and interfere with normal hormone receptor signaling throughout the body. Effective mitigation strategies are essential for preserving cellular function and structural integrity, especially in tissues like the vasculature and dermis. This is a key aspect of managing metabolic health to preserve endocrine responsiveness.