What is the Origin of Glycan Age Index?

This cutting-edge diagnostic concept originates from the field of glycomics, the study of sugar chains (glycans) attached to proteins, which are now recognized as critical regulators of protein function and immune response. The term "Glycan Age" signifies that the state of these sugar structures is a highly accurate reflection of biological aging. It represents a shift towards molecular-level diagnostics for preventative health.

What is the Mechanism of Glycan Age Index?

The index operates by analyzing the specific patterns of fucose and sialic acid residues on the Fc fragment of IgG, which dictates whether the antibody is pro-inflammatory or anti-inflammatory. A shift towards pro-inflammatory glycosylation patterns is associated with an increased Glycan Age and chronic low-grade inflammation, a known driver of age-related diseases. By quantifying this shift, the index provides a measurable target for lifestyle and therapeutic interventions aimed at modulating the immune system's inflammatory set point.

Glycan Age Index ∞ Area

Glycan Age Index

Meaning

The Glycan Age Index is a sophisticated, quantitative biomarker that measures the state of chronic systemic inflammation and immune system health by analyzing the glycosylation profile of Immunoglobulin G (IgG) antibodies. This index provides a biological age estimate that reflects the functional status of the immune system and metabolic health, often deviating significantly from chronological age. It serves as a powerful predictive tool for age-related disease risk and overall longevity potential.