Skip to main content

Glutamatergic Excitation

Meaning

Glutamatergic Excitation describes the process in the central nervous system where the neurotransmitter glutamate binds to its receptors, primarily NMDA and AMPA receptors, causing a rapid depolarization of the postsynaptic neuron. As the principal excitatory neurotransmitter in the brain, glutamate plays a crucial role in cognitive functions, including learning, memory formation, and synaptic plasticity. While essential for brain function, excessive or dysregulated glutamatergic excitation can lead to excitotoxicity, a pathological process implicated in neurodegenerative conditions. Maintaining a precise balance with inhibitory systems, like the GABAergic system, is paramount for neuronal health and stable cognitive function.