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Glutamate Buildup Management

Meaning

The clinical and physiological strategies employed to maintain optimal and non-toxic extracellular concentrations of the principal excitatory neurotransmitter, glutamate, within the delicate environment of the central nervous system. Excessive accumulation of glutamate, scientifically termed excitotoxicity, can rapidly lead to irreversible neuronal damage and severe disruption of normal brain circuit function. Effective management is crucial for protecting long-term neuronal integrity and appropriately modulating overall nervous system tone.