Glucose Homeostasis Tuning refers to the precise modulation of insulin, glucagon, and counter-regulatory hormone action to maintain blood glucose within a narrow, healthy operational range.
Origin
This concept is fundamental to endocrinology, focusing on the pancreatic-hepatic axis’s role in energy substrate management.
Mechanism
Tuning involves optimizing insulin sensitivity in peripheral tissues and ensuring appropriate hepatic glucose output, often influenced by nutrient load and systemic inflammation.
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