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Glucose-6-Phosphate Dehydrogenase

Meaning

Glucose-6-Phosphate Dehydrogenase (G6PD) is a critical metabolic enzyme that catalyzes the first committed step in the pentose phosphate pathway, a crucial biochemical route parallel to glycolysis. Its primary function is the production of NADPH, a vital reducing agent that protects red blood cells and other tissues from oxidative stress and damage. G6PD deficiency, an X-linked genetic disorder, is the most common human enzyme defect, leading to a predisposition for hemolytic anemia when exposed to certain drugs, foods, or infections. This enzyme’s activity is a key biomarker of cellular resilience and antioxidant capacity, essential for systemic health.