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Glucocorticoid Signaling Interference

Meaning

Any process, whether pathological or pharmacological, that disrupts the normal transmission and reception of signals mediated by glucocorticoid hormones, primarily cortisol, at the cellular level. This interference can result from receptor downregulation, altered hormone metabolism, or competitive binding by environmental compounds. It leads to a cascade of systemic effects, notably on immune function, metabolism, and mood regulation.