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Glucocorticoid Secretion

Meaning

Glucocorticoid secretion is the precise process by which the adrenal cortex, specifically the zona fasciculata, synthesizes and releases glucocorticoid hormones, primarily cortisol in humans, into the systemic circulation. This essential release is tightly controlled by the Hypothalamic-Pituitary-Adrenal (HPA) axis and follows a distinct, robust circadian rhythm, typically peaking in the early morning hours and declining significantly at night, with acute, powerful bursts triggered by any physiological or psychological stressor. Cortisol is the body’s primary and most vital steroid hormone, acting as the master regulator of the stress response, glucose metabolism, immune function, and systemic inflammation.