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Glucocorticoid Response Modulation

Meaning

Glucocorticoid response modulation is the physiological or clinical process of strategically altering the sensitivity or overall magnitude of a cell’s reaction to glucocorticoid hormones, with cortisol being the primary example. This modulation can occur at multiple levels, including changes to the glucocorticoid receptor expression, the activity of co-regulatory proteins, or the efficiency of downstream gene transcription events. Therapeutic strategies often aim to optimize this response to minimize the negative metabolic, immune, and cognitive consequences associated with chronic stress or receptor dysregulation.