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Glucocorticoid Response Element Binding

Meaning

Glucocorticoid Response Element Binding is a precise molecular event where the activated complex of a glucocorticoid hormone, such as cortisol, and its intracellular receptor attaches to specific DNA sequences within the cell nucleus. These specific sequences, known as Glucocorticoid Response Elements (GREs), are located in the promoter regions of target genes. This binding is the fundamental mechanism by which glucocorticoids regulate gene transcription, controlling a vast array of physiological processes, including metabolism, immunity, and stress adaptation.