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Glucocorticoid Resistance Mechanism

Meaning

Glucocorticoid Resistance Mechanism describes the biological phenomenon where target tissues exhibit a diminished or blunted response to the actions of glucocorticoid hormones, such as cortisol, despite normal or elevated circulating levels. This clinical state can lead to a failure of cortisol’s critical anti-inflammatory and metabolic regulatory effects, often resulting in systemic inflammation or an inability to properly manage stress. Understanding this mechanism is vital for addressing chronic stress-related endocrine dysfunction.