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Glucocorticoid Receptor

Meaning

The Glucocorticoid Receptor (GR) is a type of intracellular receptor protein that binds to glucocorticoid hormones, such as cortisol, mediating their profound effects on metabolism, immunity, and stress response. Found in nearly every cell in the body, the GR acts as a ligand-activated transcription factor, meaning it must first bind to its hormonal ligand before it can regulate gene expression. The sensitivity and density of these receptors are critical determinants of an individual’s response to stress and overall metabolic health.