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Glucocorticoid Receptor Re-Sensitization

Meaning

Glucocorticoid Receptor Re-Sensitization is a therapeutic objective focused on restoring the appropriate responsiveness of cellular glucocorticoid receptors (GRs) to circulating cortisol. Chronic stress or inflammation often leads to a state of functional glucocorticoid resistance, where target cells downregulate the number or sensitivity of their GRs, thereby reducing the anti-inflammatory and metabolic effects of cortisol. Achieving re-sensitization is critical for resolving chronic inflammatory states, restoring proper HPA axis negative feedback, and ensuring cortisol’s essential role in modulating the immune system and regulating energy metabolism.