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Glucocorticoid Receptor Function

Meaning

Glucocorticoid Receptor Function describes the specific biological activity of the intracellular receptor protein that mediates the effects of glucocorticoid hormones, primarily cortisol, throughout the body. This nuclear receptor is a ligand-activated transcription factor that, upon binding cortisol, translocates to the cell nucleus to regulate the expression of hundreds of genes. Its function is central to stress response, immune suppression, glucose metabolism, and inflammation resolution. Dysregulation of this function, often seen in chronic stress, leads to systemic hormonal imbalance and metabolic dysfunction.