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Glucocorticoid-Mediated Suppression

Meaning

Glucocorticoid-Mediated Suppression is the negative feedback phenomenon where elevated circulating glucocorticoids, whether from chronic endogenous stress or exogenous pharmacological administration, inhibit the secretion of corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH). This central dampening effect reduces the adrenal gland’s capacity to produce its own cortisol, leading to potential adrenal axis suppression. Recognizing this suppression is vital when managing chronic inflammatory conditions or autoimmune presentations. This is a critical component of HPA axis regulation.