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Glucagon Suppression

Meaning

Glucagon Suppression is the physiological or pharmacological process of reducing the secretion or inhibitory action of the hormone glucagon, which is primarily produced by the alpha cells of the pancreatic islets. Since glucagon’s main role is to raise blood glucose levels by promoting hepatic glucose output, its suppression is a critical mechanism for controlling hyperglycemia. This action is essential for maintaining glucose homeostasis, particularly in states of insulin resistance or overt diabetes.