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Glucagon Insulin Ratio

Meaning

The Glucagon Insulin Ratio is a critical endocrine index representing the balance between the two primary pancreatic hormones that regulate blood glucose homeostasis. Insulin, secreted by beta cells, is an anabolic hormone that lowers blood glucose by promoting cellular uptake, while glucagon, secreted by alpha cells, is a catabolic hormone that raises blood glucose by stimulating hepatic glucose production. This ratio provides a powerful, dynamic insight into the body’s metabolic state, reflecting whether it is primarily in a storage (high insulin) or mobilization (high glucagon) phase. Maintaining an appropriate ratio is fundamental for stable energy and metabolic health.