What is the Meaning of GLP-1?

GLP-1, or Glucagon-like Peptide-1, is an incretin hormone secreted by L-cells in the distal small intestine primarily in response to nutrient ingestion, playing a pivotal role in glucose homeostasis and satiety signaling. Its actions are crucial for modulating postprandial insulin secretion and suppressing glucagon release. Clinically, it represents a key target for managing metabolic dysregulation.

What is the Origin of GLP-1?

The term originates from its chemical structure, identifying it as a peptide derived from proglucagon, found in the gut (Gastrointestinal tract). Its physiological significance became apparent through studies linking nutrient sensing in the gut to pancreatic endocrine function. It is a vital component of the entero-insular axis.

What is the Mechanism of GLP-1?

GLP-1 exerts its effects by binding to the GLP-1 receptor (GLP-1R) on pancreatic beta cells, leading to glucose-dependent insulin secretion, which enhances peripheral glucose uptake. Furthermore, it acts centrally to increase satiety signals and peripherally to slow gastric emptying, reducing the rate of substrate entry into circulation. These combined actions contribute significantly to blunting postprandial hyperglycemia.

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Can GLP-1 Medications Influence Reproductive Hormonal Balance?

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