What is the Origin of GLP-1 Therapy?

The term originates from the native peptide GLP-1, which is secreted from intestinal L-cells postprandially in response to nutrient ingestion. The 'Therapy' aspect signifies its deployment as a structured medical treatment regimen.

What is the Mechanism of GLP-1 Therapy?

These agonists bind to the GLP-1 receptor, stimulating glucose-dependent insulin secretion from pancreatic beta cells while simultaneously inhibiting inappropriate glucagon release. Moreover, they exert central effects by promoting satiety and delaying gastric emptying rates. These coordinated actions lead to improved glucose homeostasis and reduced caloric intake.

GLP-1 Therapy

Meaning

GLP-1 Therapy utilizes synthetic agonists that mimic the action of the endogenous incretin hormone Glucagon-Like Peptide-1, targeting its specific receptor. These pharmacological agents are cornerstone treatments for improving glycemic control in Type 2 Diabetes Mellitus and are increasingly recognized for their utility in chronic weight management. Understanding their pleiotropic effects is key to modern metabolic care.