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GLP-1 Secretion

Meaning

GLP-1 secretion refers to the precise release of Glucagon-like Peptide-1, an essential incretin hormone produced primarily by the L-cells of the distal small intestine and colon in response to nutrient ingestion. This peptide plays a crucial, multifaceted role in glucose homeostasis by stimulating insulin secretion in a glucose-dependent manner and simultaneously suppressing glucagon release. Clinically, enhancing its secretion or mimicking its action is a primary therapeutic strategy for managing type 2 diabetes and obesity due largely to its potent appetite-suppressing and metabolic effects.