What is the Origin of GLP-1 Metabolic Effect?

GLP-1 is an endogenous peptide hormone secreted from L-cells in the ileum and colon following nutrient ingestion, highlighting its origin as a key component of the gut-brain axis feedback loop governing postprandial metabolism. Its discovery revolutionized diabetes management.

What is the Mechanism of GLP-1 Metabolic Effect?

The primary mechanism involves GLP-1 binding to its G-protein coupled receptor (GLP-1R) on pancreatic beta cells, activating the cAMP pathway to potentiate insulin release only when glucose levels are elevated. Furthermore, central nervous system signaling via the hypothalamus contributes to appetite regulation, offering dual control over metabolic balance.

GLP-1 Metabolic Effect ∞ Area

GLP-1 Metabolic Effect

Meaning

The comprehensive physiological impact mediated by Glucagon-Like Peptide-1 (GLP-1), an incretin hormone, which includes enhancing glucose-dependent insulin secretion, suppressing glucagon release, promoting satiety, and slowing gastric emptying. These actions collectively improve glycemic control.