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GLP-1 Dynamics

Meaning

GLP-1 Dynamics refers to the study of the synthesis, rapid secretion, systemic action, and subsequent metabolic fate of Glucagon-like peptide-1 (GLP-1), an essential incretin hormone central to both glucose homeostasis and the regulation of appetite and satiety. These dynamics encompass the rapid release of GLP-1 following nutrient ingestion, its very short half-life due to rapid degradation by the DPP-4 enzyme, and its profound systemic effects on pancreatic beta cells and the central nervous system. Optimizing these GLP-1 dynamics is a major therapeutic target for the clinical management of type 2 diabetes and the promotion of healthy, sustainable weight management.