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Global Peptide Availability

Meaning

Global peptide availability refers to the systemic concentration and distribution of therapeutic or endogenous signaling peptides throughout the body following administration or endogenous production. This metric is crucial for determining the overall biological efficacy and therapeutic dosing of peptide-based interventions, which is essential for precision medicine. It encompasses absorption, distribution, metabolism, and excretion (ADME) kinetics to define the effective concentration at target receptors in various tissues. Achieving sufficient global availability is a primary challenge in peptide drug development.