Skip to main content

Gland Functional Mass

Meaning

Gland functional mass refers to the total volume of endocrine tissue within a gland that is actively synthesizing and secreting hormones, distinguishing it from non-functional stromal or pathological tissue. This metric is a more accurate physiological indicator of a gland’s capacity than its gross anatomical size alone, reflecting the true reserve and secretory potential of the endocrine organ. For instance, in the thyroid or adrenal glands, a reduced functional mass can lead to overt hormonal insufficiency, necessitating replacement therapy. Clinicians use indirect measures, such as basal hormone levels and dynamic stimulation tests, to estimate this crucial functional capacity. Optimal functional mass is essential for maintaining endocrine homeostasis.