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GIP/GLP-1 Receptor Agonist

Meaning

A GIP/GLP-1 Receptor Agonist is a class of pharmacological agents that activate both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor. These agents are synthetic mimetics of the naturally occurring incretin hormones, which are released by the gut in response to nutrient ingestion. By stimulating these dual receptors, they enhance glucose-dependent insulin secretion from the pancreatic beta cells, modulate glucagon release, and slow gastric emptying. These powerful metabolic regulators are increasingly utilized in the clinical management of type 2 diabetes and for significant body weight reduction, demonstrating a profound impact on metabolic and hormonal homeostasis.