What is the Origin of GHSR?

The term is an acronym for Growth Hormone Secretagogue Receptor, derived from the physiological observation that certain synthetic compounds, termed secretagogues, could stimulate growth hormone release. The endogenous ligand for this receptor was later identified as ghrelin, a name derived from the Proto-Indo-European root 'ghre' meaning 'to grow.' Its discovery in the late 1990s revolutionized the understanding of the gut-brain axis and the hormonal control of hunger and energy expenditure. This molecular entity is central to the study of endocrinology and metabolic function.

What is the Mechanism of GHSR?

Upon binding its ligand, ghrelin, GHSR undergoes a conformational change that activates associated G proteins, initiating intracellular signaling cascades, most notably the phospholipase C pathway. In the anterior pituitary, this activation leads to the release of growth hormone (GH) by somatotroph cells. Within the hypothalamus, GHSR signaling promotes appetite and energy intake. The receptor's constitutive activity, meaning it is partially active even without a ligand, makes it a unique and complex target for pharmacological manipulation in the context of metabolic and hormonal wellness.

GHSR ∞ Area ∞ Library 2

GHSR

Meaning

GHSR stands for Growth Hormone Secretagogue Receptor, a G protein-coupled receptor primarily known for its role in mediating the potent effects of the peptide hormone ghrelin. This receptor is widely distributed throughout the body, with high concentrations in the hypothalamus, pituitary gland, and other peripheral tissues like the pancreas and gut. GHSR is a critical component of the neuroendocrine system that regulates appetite, energy balance, and the pulsatile secretion of growth hormone. Modulating its activity offers a therapeutic avenue for addressing conditions related to growth, metabolism, and appetite control.

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HRTioOctober 8, 2025