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GHSR Signaling

Meaning

GHSR Signaling refers to the intricate biochemical communication pathway initiated by the Growth Hormone Secretagogue Receptor (GHSR), which is primarily known for mediating the effects of the peptide hormone ghrelin. This signaling cascade plays a crucial role in regulating energy homeostasis, stimulating appetite, and promoting the release of Growth Hormone (GH) from the pituitary gland. In the broader hormonal health landscape, GHSR signaling is a key neuroendocrine link between the gut, the brain, and the somatotropic axis. Modulating this pathway is an area of significant clinical interest for managing growth disorders, metabolic dysfunction, and body composition.