What is the Origin of GHSR Polymorphism?

The term combines the abbreviation for the ghrelin receptor gene (GHSR) with the genetic concept of polymorphism, which is derived from Greek words meaning "many forms." The clinical relevance of this term emerged from molecular endocrinology research that sought to explain inter-individual variability in metabolic traits. Identifying these variations helps link genetic predisposition to specific physiological and hormonal phenotypes related to feeding behavior and growth.

What is the Mechanism of GHSR Polymorphism?

The GHSR is a G protein-coupled receptor that, when activated by ghrelin, initiates intracellular signaling pathways to stimulate growth hormone release and promote food intake. A GHSR polymorphism can alter the receptor's affinity for ghrelin or modify its signal transduction efficiency. This change in receptor function can lead to subtle but systemic alterations in the hypothalamic control of energy homeostasis, potentially contributing to variability in body mass index, glucose metabolism, and the overall efficiency of the somatotropic axis.

GHSR Polymorphism

Meaning

GHSR polymorphism refers to a common variation in the DNA sequence of the gene encoding the Growth Hormone Secretagogue Receptor (GHSR), which is the primary receptor for the hunger-stimulating hormone ghrelin. A polymorphism is a variation present in more than one percent of the population, and specific GHSR gene variants can alter the receptor’s function or expression. These genetic differences can influence an individual’s endocrine profile, impacting appetite regulation, energy balance, and overall metabolic health.