What is the Origin of GHS Secretagogues?

The term originates from the discovery of the ghrelin receptor and the subsequent identification of non-GH-releasing hormone peptides that potently stimulated GH release. The word 'secretagogue' itself is derived from Greek, meaning 'to lead to secretion,' precisely describing the function of these compounds. This classification was necessary to distinguish these agents from direct GH replacement and GHRH analogs, establishing a new pharmacological category in endocrinology.

What is the Mechanism of GHS Secretagogues?

The core mechanism involves binding to and activating the GHS-R1a receptor in the anterior pituitary and the arcuate nucleus of the hypothalamus. Activation of this receptor initiates an intracellular cascade that mobilizes GH-containing vesicles for release. A significant component of their mechanism is the suppression of somatostatin, the potent physiological inhibitor of GH secretion. This combined action—direct stimulation and removal of inhibition—results in a powerful, physiological, and often synergistic increase in circulating GH levels.

GHS Secretagogues

Meaning

GHS Secretagogues are a class of compounds, both endogenous and synthetic, that function as Growth Hormone Secretagogues (GHS) by promoting the release of Growth Hormone (GH) from the pituitary gland. These agents act on the ghrelin receptor, also known as the GHS receptor (GHS-R1a), a distinct pathway from the hypothalamic GHRH. Their clinical utility lies in their ability to restore age-related decline in GH pulsatility, which is crucial for maintaining lean body mass, bone density, and metabolic homeostasis.