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GHS Receptor Binding

Meaning

GHS Receptor Binding refers to the specific molecular interaction where a Ghrelin Secretagogue (GHS) molecule, either an endogenous peptide like ghrelin or a synthetic analogue, attaches to the Growth Hormone Secretagogue Receptor (GHSR) on target cells, primarily in the pituitary gland and hypothalamus. This binding event initiates a powerful signal transduction cascade that culminates in the pulsatile release of Growth Hormone (GH). Understanding this binding affinity and subsequent agonism is central to developing therapeutic peptides aimed at modulating the somatotropic axis for benefits in body composition, tissue repair, and metabolic health. It is a precise mechanism for pharmacological control over the body’s growth and repair systems.