GHRP Peptides refers to Growth Hormone Releasing Peptides, which are synthetic oligopeptides designed to stimulate the somatotropic axis by acting on the ghrelin receptor in the pituitary gland. They are potent secretagogues for endogenous Growth Hormone release.
Origin
These compounds originated from research into appetite regulation and pituitary function, stemming from the discovery of ghrelin’s role as the ‘hunger hormone’ and its subsequent identification as a GH-releasing agent.
Mechanism
GHRPs bind to the GHS-R1a receptor, bypassing the normal inhibitory control of somatostatin to directly signal the anterior pituitary. This action results in a pulsatile surge of Growth Hormone, which subsequently stimulates IGF-1 production in the liver, supporting tissue repair and anabolism.
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