What is the Origin of GHRP-2?

The origin of GHRP-2 stems from the pharmaceutical research of the late 20th century, which sought synthetic compounds to mimic the natural actions of met-enkephalin-derived peptides on growth hormone release. It is a second-generation compound following GHRP-6, synthesized to be a more potent and specific stimulator of GH secretion. Its formal name is Pralmorelin, signifying its place as a developed pharmacological agent within the class of GHS compounds.

What is the Mechanism of GHRP-2?

GHRP-2 operates by acting as a powerful agonist of the Growth Hormone Secretagogue Receptor (GHS-R), also known as the ghrelin receptor, located primarily in the pituitary and hypothalamus. Binding to this receptor directly stimulates the somatotroph cells to release Growth Hormone. Furthermore, its action may involve functionally antagonizing the inhibitory effect of somatostatin, the body's natural GH-suppressing hormone, thus promoting a robust and pulsatile surge of endogenous GH.

GHRP-2

Meaning

GHRP-2, or Growth Hormone-Releasing Peptide-2, is a synthetic, non-natural hexapeptide classified as a potent Growth Hormone Secretagogue (GHS). This peptide is utilized in clinical and research settings to stimulate the pituitary gland, leading to a significant, acute release of endogenous Growth Hormone (GH). It is often employed in diagnostic tests for GH deficiency and in protocols aimed at enhancing body composition, recovery, and overall vitality.