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GHRH-Somatostatin Oscillator

Meaning

The GHRH-Somatostatin Oscillator is the primary neuroendocrine control mechanism located in the hypothalamus that dictates the pulsatile release pattern of Growth Hormone (GH) from the anterior pituitary gland. This oscillator involves the rhythmic, reciprocal secretion of two key hypothalamic neuropeptides: Growth Hormone-Releasing Hormone (GHRH), which stimulates GH release, and Somatostatin (SRIF), which inhibits it. The dynamic balance and coordinated timing of these two opposing signals are responsible for the characteristic, intermittent bursts of GH secretion observed throughout the day, particularly during sleep. Optimal function of this oscillator is crucial for maintaining a healthy somatotropic axis.