What is the Origin of GHRH Secretagogues?

The term is derived from the Greek 'secretagogue,' meaning 'to incite secretion,' combined with the acronym for Growth Hormone-Releasing Hormone. This reflects their primary pharmacological action on the neuroendocrine control center.

What is the Mechanism of GHRH Secretagogues?

Secretagogues bind to specific receptors on hypothalamic neurons, triggering intracellular signaling cascades that result in the depolarization and exocytosis of GHRH-containing vesicles. The released GHRH then travels to the pituitary to initiate GH release, thereby modulating systemic anabolic and metabolic functions.

GHRH Secretagogues

Meaning

GHRH Secretagogues are compounds administered to stimulate the endogenous release of Growth Hormone-Releasing Hormone (GHRH) from the hypothalamus into the portal circulation. These agents are employed clinically to enhance the natural pulsatile secretion of growth hormone (GH) from the anterior pituitary gland. They represent a targeted approach to somatotropic axis support.