What is the Meaning of GHRH Receptors?

GHRH receptors, or Growth Hormone-Releasing Hormone Receptors, are G-protein coupled receptors located primarily on the somatotroph cells of the anterior pituitary gland. These receptors are the primary biological targets for GHRH, a hypothalamic peptide, which stimulates the synthesis and pulsatile release of Growth Hormone (GH). The density and sensitivity of these receptors are crucial determinants of the body's overall GH secretion capacity and are integral to the somatotropic axis.

What is the Origin of GHRH Receptors?

The receptor's discovery followed the identification and structural characterization of its ligand, Growth Hormone-Releasing Hormone, in the early 1980s. This finding completed the classical hypothalamic-pituitary-peripheral axis for growth hormone regulation. The term is descriptive of the receptor's function: to receive the GHRH signal.

What is the Mechanism of GHRH Receptors?

Upon binding of GHRH to the GHRH receptor on the somatotroph cell surface, the receptor activates an intracellular signaling cascade, primarily involving the Gs protein and the subsequent increase of cyclic AMP (cAMP) and protein kinase A (PKA) activity. This cascade leads to two key actions: the transcriptional activation of the GH gene, promoting synthesis, and the mobilization of intracellular calcium, which triggers the exocytosis and release of stored GH into the systemic circulation. This pulsatile release pattern is essential for GH's downstream metabolic and growth effects.

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