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GHRH Antagonist

Meaning

A GHRH Antagonist is a synthetic compound designed to block the biological action of Growth Hormone-Releasing Hormone, a key hypothalamic peptide. By binding to and inhibiting the GHRH receptors on the pituitary gland, this agent prevents the signaling cascade that normally stimulates the secretion of Growth Hormone. This class of medication is clinically utilized to manage conditions characterized by excessive Growth Hormone production, such as acromegaly, thereby helping to normalize circulating levels of the downstream hormone Insulin-like Growth Factor-1. The precise modulation of this axis is essential for metabolic and tissue health.