GHRH Analogue Administration refers to the clinical practice of introducing a synthetic compound that mimics the action of Growth Hormone-Releasing Hormone (GHRH) into the body. These analogues, such as Sermorelin or Tesamorelin, stimulate the pituitary gland to secrete its own endogenous growth hormone (GH) in a pulsatile, physiological manner. This therapeutic approach is distinct from administering exogenous GH, as it maintains the natural feedback loops of the hypothalamic-pituitary-somatotropic axis. It is utilized to address age-related decline in GH and IGF-1 levels, aiming for improved body composition and metabolic function.
Origin
This pharmacological term stems from neuroendocrinology and clinical therapeutics, combining the name of the native hormone GHRH with “analogue,” indicating a structurally similar, synthetic version. The development of these compounds was driven by the desire to harness the anabolic and restorative effects of GH while minimizing the side effects associated with direct GH injection. This administration method is a refined strategy for somatotropic axis optimization.
Mechanism
The administered GHRH analogue binds to and activates the GHRH receptor on somatotroph cells within the anterior pituitary gland. This binding initiates an intracellular signaling cascade, primarily involving the cAMP pathway, which ultimately leads to the synthesis and pulsatile release of stored growth hormone into the systemic circulation. By leveraging the body’s natural release mechanisms, this approach promotes a more physiological pattern of GH secretion, which then drives the hepatic production of Insulin-like Growth Factor 1 (IGF-1).
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