What is the Origin of GHRfl/d3?

The abbreviation GHR refers to the Growth Hormone Receptor, while 'fl' denotes the full-length receptor and 'd3' signifies the deletion of the third exon. This genetic polymorphism was identified through molecular endocrinology research focusing on growth hormone sensitivity and action, establishing its role as a key genetic variant.

What is the Mechanism of GHRfl/d3?

The GHRfl/d3 variant is hypothesized to possess a higher binding affinity for circulating growth hormone and may lead to enhanced intracellular signaling, particularly the JAK2-STAT5 pathway, compared to the full-length receptor. This differential signaling capacity can influence individual responses to growth hormone secretagogues and impact body composition, bone mineral density, and overall metabolic health outcomes.

GHRfl/d3 ∞ Area

GHRfl/d3

Meaning

A specialized nomenclature representing a truncated variant of the Growth Hormone Receptor (GHR) with specific functional implications in human physiology and endocrinology. This receptor isoform, lacking the exon 3-encoded amino acids, exhibits altered signaling properties compared to the full-length GHR.

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Can Peptide Receptor Polymorphisms Alter Growth Hormone Therapy Outcomes?

Peptide receptor polymorphisms introduce genetic variations that can significantly modulate an individual's sensitivity and response to growth hormone therapy.

∞ GHRd3
∞ SOCS2
∞ Growth Hormone Receptor Polymorphism

HRTioJuly 27, 2025

GHRfl/d3

Meaning

Origin

Mechanism

Can Peptide Receptor Polymorphisms Alter Growth Hormone Therapy Outcomes?

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