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Ghrelin Signal Attenuation

Meaning

Ghrelin signal attenuation is the physiological or pharmacological process of reducing the intensity or effect of the hunger-stimulating hormone ghrelin. Ghrelin, often termed the “hunger hormone,” is primarily secreted by the stomach and signals a state of energy deficit to the brain. Attenuation aims to decrease the perceived level of hunger, thereby supporting a reduction in caloric intake and facilitating weight management efforts. This targeted approach seeks to normalize an overactive hunger drive that can sabotage adherence to dietary protocols.