What is the Origin of Ghrelin Rhythm Disruption?

This concept emerges from endocrinology and chronobiology, focusing on the rhythmic secretion of the peptide ghrelin, primarily from the stomach. Disruption refers to the deviation from the natural, predictable, and beneficial pulsatile pattern. Rhythm describes the predictable 24-hour cycle of hormone release.

What is the Mechanism of Ghrelin Rhythm Disruption?

Ghrelin is acutely suppressed by nutrient ingestion, but its underlying circadian rhythm is set by the master clock. Inconsistent feeding schedules or chronic stress can decouple the peripheral ghrelin secretion pattern from the central clock, leading to a loss of the anticipatory pre-meal peak and a blunted post-meal suppression. This hormonal confusion impairs the central satiety mechanisms, promoting overconsumption and contributing to a positive energy balance.

Ghrelin Rhythm Disruption ∞ Area

Ghrelin Rhythm Disruption

Meaning

An irregularity or flattening of the normal circadian pattern of the hunger-stimulating hormone ghrelin, often resulting from inconsistent eating times or chronic sleep deprivation. The healthy ghrelin rhythm typically peaks before meals and reaches its nadir post-meal, but disruption leads to an inappropriate, sustained elevation or erratic signaling, contributing to increased appetite and potential metabolic dysregulation. This hormonal imbalance undermines effective appetite control.