What is the Origin of Ghrelin Production?

Ghrelin was discovered in 1999 and named based on its function as a Gh-releasing peptide, with the suffix derived from the Proto-Indo-European root ghre, meaning "to grow." This etymology highlights its connection to Growth Hormone release and metabolic signaling. It is a relatively recent addition to the pantheon of key endocrine regulators.

What is the Mechanism of Ghrelin Production?

Ghrelin levels typically rise sharply before meals and decrease rapidly after eating, directly stimulating appetite and promoting adipogenesis. The hormone acts on the arcuate nucleus of the hypothalamus to increase the expression of neuropeptide Y and Agouti-related peptide, which are potent orexigenic signals. Proper regulation of ghrelin production is essential for metabolic homeostasis and weight management.

Ghrelin Production ∞ Area

Ghrelin Production

Meaning

Ghrelin Production refers to the physiological process of synthesizing and secreting the peptide hormone ghrelin, primarily by specialized cells in the stomach lining. Ghrelin is unique among gastrointestinal hormones as it is the main endogenous ligand for the growth hormone secretagogue receptor, earning it the clinical designation of the “hunger hormone.” Its pulsatile release signals energy need to the hypothalamus.