Question 1

What is the Meaning of Ghrelin/Growth Hormone Secretagogue Receptor?

Accepted Answer

The Ghrelin/Growth Hormone Secretagogue Receptor, universally known as GHSR, is a G protein-coupled receptor that is primarily recognized as the specific binding site for the potent orexigenic (appetite-stimulating) peptide hormone ghrelin. Located strategically in the hypothalamus, the anterior pituitary gland, and various other peripheral tissues, this receptor functions as a key nexus in the central regulation of systemic energy homeostasis, body weight control, and the critical pulsatile secretion of Growth Hormone (GH). Its activation integrates physiological signals directly related to acute nutritional status with the body's overall anabolic and regenerative drive.

Question 2

What is the Origin of Ghrelin/Growth Hormone Secretagogue Receptor?

Accepted Answer

The receptor was initially discovered in the early 1990s as the high-affinity binding site for a class of synthetic molecules designed to potently stimulate GH release, which led to its initial naming as the Growth Hormone Secretagogue Receptor. Ghrelin, the true endogenous peptide ligand that activates this receptor, was only definitively isolated and identified later in 1999, necessitating the combined terminology to fully describe the receptor's complete biological significance. The name thus reflects the dual nature of its function: responding to ghrelin and inducing GH secretion.

Question 3

What is the Mechanism of Ghrelin/Growth Hormone Secretagogue Receptor?

Accepted Answer

When the ghrelin peptide binds to the GHSR, it initiates a complex intracellular signaling cascade that primarily acts upon the somatotroph cells of the anterior pituitary gland to stimulate the rapid, pulsatile release of Growth Hormone. Concurrently, GHSR signaling in specific nuclei of the hypothalamus enhances the sensation of appetite and promotes increased food intake. This dual, coordinated mechanism effectively links the physiological state of negative energy balance, which is signaled by elevated ghrelin, directly to increased GH release, thereby promoting anabolism, efficient nutrient utilization, and playing a central role in overall metabolic and hormonal regulation.

Ghrelin/Growth Hormone Secretagogue Receptor

Meaning

Origin

Mechanism

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