What is the Origin of Ghrelin Agonists?

The term is a compound of "ghrelin," derived from the root ghre (meaning "grow" in Proto-Indo-European) and "agonist," from the Greek agonistes (contestant), referring to a substance that initiates a physiological response when combined with a receptor. Ghrelin itself was discovered in 1999 as the natural ligand for the GH secretagogue receptor.

What is the Mechanism of Ghrelin Agonists?

Ghrelin agonists bind to the GHSR-1a receptor, which is highly expressed in the hypothalamus and the pituitary gland. Receptor activation triggers a G-protein-coupled signaling cascade, leading to the release of growth hormone and stimulating the orexigenic (appetite-stimulating) pathways in the brain. This dual action on both metabolic and endocrine function is central to their physiological role.

Ghrelin Agonists

Meaning

Ghrelin agonists are a class of pharmacological compounds that activate the ghrelin receptor (Growth Hormone Secretagogue Receptor, GHSR-1a), mimicking the action of the endogenous hormone ghrelin. These agents are primarily known for their potent stimulatory effect on appetite and their ability to promote the secretion of growth hormone (GH) from the pituitary gland. Clinically, they are explored for treating conditions like cachexia and growth hormone deficiency, where anabolic drive is compromised.

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Ghrelin Agonists

Meaning

Origin

Mechanism

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