Skip to main content

Ghrelin Agonist

Meaning

A Ghrelin Agonist is a compound, either endogenous or pharmaceutical, that binds to and activates the Ghrelin Receptor (GHSR-1a), mimicking the action of the native hormone ghrelin. This activation primarily targets the hypothalamus and pituitary gland, resulting in a potent orexigenic effect, which stimulates appetite and food intake. Beyond its role in energy balance, a ghrelin agonist also typically stimulates the release of Growth Hormone (GH) from the anterior pituitary. Clinical interest focuses on its potential therapeutic application in conditions involving cachexia or growth hormone deficiency.